A Real Case: How One Woman Overcame Chronic Fatigue with MTHFR Diagnosis

Introduction

Chronic fatigue is one of the most frustrating conditions to live with. It’s invisible, often misunderstood, and frequently misdiagnosed. That was the case for Emma, a 38-year-old marketing executive who went from doctor to doctor searching for answers to her persistent exhaustion.

What finally changed her life wasn’t another prescription—it was a methylation test that revealed a hidden genetic imbalance: a MTHFR mutation. Thanks to a personalized plan from GeneusDNA, Emma reclaimed her energy, clarity, and quality of life.

Emma’s Story: When Fatigue Becomes Debilitating

For years, Emma had battled:

• Persistent tiredness even after 8 hours of sleep
• Brain fog that made it hard to focus at work
• Frequent headaches and sensitivity to stress
• A growing dependence on caffeine just to get through the day

Her lab results always came back “normal,” and she was told it was likely stress or hormonal changes. But deep down, Emma felt something else was wrong.

Deciding to Try DNA Testing

On a recommendation from a friend, Emma ordered a methylation and genetic test from GeneusDNA. It was non-invasive, just a saliva sample she sent in from home.

What she received wasn’t just a list of genes—it was a map of how her body functions, and where support was needed.

The Breakthrough: MTHFR Homozygous C677T

Emma’s GeneusDNA results revealed:

• Homozygous MTHFR C677T: Her body had a reduced ability to convert folic acid into methylfolate, impacting energy, detox, and brain chemistry.
• Elevated homocysteine levels: A marker of poor methylation and cardiovascular risk.
• Slow COMT activity: Which contributed to emotional sensitivity and poor stress recovery.
• Detox gene weaknesses in GST and NQO1 pathways.

In short: Emma’s fatigue wasn’t “in her head.” It was in her methylation pathways.

The GeneusDNA Plan That Changed Everything

GeneusDNA built a personalized plan for Emma based on her results, including:

Supplement Adjustments

• Switched from a generic multivitamin to methylated B complex: 5-MTHF, methyl B12, P-5-P
• Added NAC and magnesium to support detox and energy metabolism
• Incorporated glutathione support for oxidative stress relief

Nutrition and Lifestyle

• Increased intake of folate-rich foods (spinach, avocado, lentils)
• Eliminated foods with synthetic folic acid (like processed cereals and energy bars)
• Adopted gentle movement (yoga, walking) and breathwork to reduce nervous system stress

The Results: From Burnout to Balance

Within 30 Days:

• Emma reported more consistent energy throughout the day
• Brain fog began to lift

By Month 3:

• She returned to her morning workouts
• Felt emotionally more balanced and resilient
• No longer needed caffeine to function

Today:

Emma calls her methylation test the “turning point” in her health. She still follows her personalized protocol and uses the GeneusDNA platform to track and optimize her progress.

Lessons from Emma’s Journey

• Chronic fatigue has a root cause—and it’s not always obvious.
• Genetic testing can reveal hidden imbalances, especially related to methylation.
• Targeted supplementation and nutrition based on your genes can be life-changing.

How GeneusDNA Can Help You

Whether you're battling chronic symptoms or optimizing wellness, GeneusDNA provides:

• Full methylation pathway analysis
• Actionable plans based on your genetics
• 500+ insights into your health, risk, and performance potential

Don’t guess. Test—and transform your life, just like Emma did.

Written by: Dr. Arnond Kitnitchee