Gary Brecka’s Daily Supplement Stack for Optimal Health

Introduction

Gary Brecka, human biologist and pioneer in personalized wellness, has built a reputation for transforming lives through DNA-driven health protocols. At the core of his system is a carefully curated daily supplement stack designed to optimize methylation, energy, mood, and cellular function.

Whether you’re an athlete, executive, or everyday biohacker, Brecka’s stack is a model of precision supplementation—tailored to address common genetic bottlenecks like MTHFR mutations, detox inefficiencies, and neurotransmitter imbalances.

In this guide, we break down Gary Brecka’s go-to supplements, explain why they work, and show how GeneusDNA offers targeted equivalents for those ready to biohack their biology.

Why Supplements Matter in Methylation and Biohacking

Methylation affects hundreds of functions in the body, from mental focus and mood to cardiovascular health and detoxification. Many individuals, especially those with methylation gene mutations, can't convert common nutrients into usable forms efficiently—making targeted supplementation essential.

Gary Brecka’s stack focuses on active forms of essential vitamins and minerals to bypass metabolic roadblocks and ensure optimal absorption.

Gary Brecka’s Core Supplement Stack

1. Methylfolate (5-MTHF)

• Purpose: Active folate for DNA synthesis and methylation
• Why: Supports neurotransmitter production and reduces homocysteine
• GeneusDNA Equivalent: Custom 5-MTHF formula based on your MTHFR status

2. Methylcobalamin (Vitamin B12)

• Purpose: Energy production and neurological function
• Why: Bypasses B12 absorption issues and works synergistically with folate
• GeneusDNA Equivalent: Methyl B12 protocol calibrated to your COMT/MTRR genes

3. P-5-P (Vitamin B6 Active Form)

• Purpose: Homocysteine metabolism, mood, and hormonal balance
• Why: Supports neurotransmitter function, especially serotonin and dopamine

4. Magnesium Glycinate

• Purpose: Calms the nervous system, supports over 300 enzymatic functions
• Why: Helps regulate stress response, detoxification, and sleep

5. Vitamin D3 + K2

• Purpose: Immunity, mood balance, and calcium regulation
• Why: K2 ensures calcium goes to bones—not arteries

6. Omega-3 Fatty Acids (EPA/DHA)

• Purpose: Brain health, anti-inflammation, cellular function
• Why: Helps regulate methylation and gene expression

7. NAC (N-Acetyl Cysteine)

• Purpose: Precursor to glutathione (master antioxidant)
• Why: Supports detox pathways and reduces oxidative stress

8. Zinc + Selenium

• Purpose: Thyroid function, immune regulation, methylation co-factors

9. Probiotics and Gut Support

• Purpose: Gut-brain connection, nutrient absorption
• Why: A healthy gut microbiome supports folate and B vitamin metabolism

Additional Biohacking Support Brecka Uses

• Hydration with electrolytes
• Red light therapy
• Hyperbaric oxygen therapy
• Intermittent fasting with nutrient cycling

GeneusDNA Parallels to the Brecka Protocol

GeneusDNA's testing platform allows users to replicate and customize Brecka's stack with precision by analyzing:

• MTHFR, COMT, and MTRR mutations
• Detox capacity (GST, CYP genes)
• Neurotransmitter gene performance
• Epigenetic age and methylation efficiency

Based on your DNA, GeneusDNA delivers:

• Tailored supplement stacks using methylated nutrients
• Dosage recommendations adjusted to your metabolism and gene expression
• Guided programs that evolve as your biology changes

Whether you’re starting your health optimization journey or enhancing an advanced protocol, GeneusDNA helps you do it Brecka-style—with data, precision, and results.

Written by: Dr. Arnond Kitnitchee