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Polygenic Risk Scores (PRS) Explained: When Thousands of SNPs Add Up to One Risk Estimate
Genetics
Health
Polygenic Risk Scores (PRS) Explained: When Thousands of SNPs Add Up to One Risk Estimate
A Polygenic Risk Score (PRS) combines thousands of SNPs into one risk estimate. Learn how it works, what it is useful for, and its key limitations — population bias and the fact that it is probabilistic, not diagnostic.
Blog Author Picture By
Dr. Kaet (Lukkaet Laoprapaipan)
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Sep 03, 2026
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117
The Genetics of Handedness: Why Only ~10% Are Left-Handed
Did you know
Genetics
The Genetics of Handedness: Why Only ~10% Are Left-Handed
Roughly 10% of people worldwide are left-handed, a ratio stable for millennia. Handedness is partly heritable but polygenic, driven by many genes rather than one, with environment playing a role too. Let us unpack the fun science.
Blog Author Picture By
GeneusDNA
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Sep 03, 2026
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107
Copy Number Variation (CNV): When Whole Chunks of DNA Are Deleted or Duplicated, and How It Differs from SNPs
Genetics
Research
Copy Number Variation (CNV): When Whole Chunks of DNA Are Deleted or Duplicated, and How It Differs from SNPs
A CNV is when a whole segment of DNA is deleted or duplicated, unlike a SNP that changes just one letter. Learn how CNVs shape health and normal human variation.
Blog Author Picture By
Dr. Kaet (Lukkaet Laoprapaipan)
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Sep 03, 2026
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116
Spermidine and Autophagy: Dietary Sources, Cellular Renewal, and the Honest Evidence
Health
Dietary supplement
Spermidine and Autophagy: Dietary Sources, Cellular Renewal, and the Honest Evidence
Spermidine is a compound in foods like wheat germ, aged cheese, and natto that may induce autophagy, the cell's self-cleaning process. Here is an honest look at what the science does and does not yet show.
Blog Author Picture By
Alis Lalishat
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Sep 03, 2026
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99
The Genetic Risk of Type 2 Diabetes: What TCF7L2 and Your Polygenic Risk Score Really Tell You
Health
Genetics
The Genetic Risk of Type 2 Diabetes: What TCF7L2 and Your Polygenic Risk Score Really Tell You
Genes like TCF7L2 and polygenic risk scores raise the odds of type 2 diabetes only modestly. Diet, activity and body weight still play a far more decisive role.
Blog Author Picture By
Dr. Arnond Kitnitchee
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Sep 03, 2026
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92
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